OBJECTIVE: To systematically evaluate the efficacy of sodium creatine phosphate combined with vitamin C in the treatment of pediatric viral myocarditis

so as to provide new therapeutic strategies and application basis for clinical treatment of pediatric viral myocarditis. METHODS: CNKI

CBM

Wanfang database

VIP database and PubMed were retrieved to collect the randomized controlled trial of sodium creatine phosphate combined with vitamin C in the treatment of pediatric viral myocarditis（ the control group received conventional treatment

while the observation group was treated with sodium creatine phosphate combined with vitamin C）. Literature that met the inclusion criteria was analyzed by using RevMan 5. 3 software（ Meta-analysis）. RESULTS: Totally 17 literature were collected

including 1 592 patients. Meta analysis results showed that the total effective rate in the observation group was significantly higher than that in the control group

and the difference was statistically significant（ OR = 4. 57

95%CI = 3. 10-6. 73

P<0. 000 01）. Serum creatine kinase（ MD =-38. 38

95%CI =-65. 76--10. 99

P = 0. 006） and lactate dehydrogenase（ MD =-42. 76

95% CI =-78. 83--6. 68

P = 0. 02） were significantly lower in the observation group than those in the control group

with statistically significant differences. The cardiac troponin I level in the observation group was lower than that in the control group

yet the difference was not statistically significant（ MD =-0. 15

95%CI =-0. 17--0. 13

P = 0. 30）. During the treatment

no adverse drug reactions were observed in both groups. CONCLUSIONS: Based on current studies

creatine phosphate combined with vitamin C is more effective than conventional treatment in the treatment of viral myocarditis in children

which provides evidence for the clinical use of creatine phosphate combined with vitamin C in the treatment of viral myocarditis in children.