OBJECTIVE: To systematically evaluate the efficacy and safety of paclitaxel combined with carboplatin synchronized with radiotherapy and chemotherapy in the treatment of cervical cancer. METHODS: Chinese and English database were retrieved to collect the randomized controlled trial of paclitaxel combined with carboplatin synchronized with radiotherapy and chemotherapy in the treatment of cervical cancer（ the control group was treated with radiotherapy alone

while the observation group received paclitaxel combined with carboplatin synchronized with radiotherapy and chemotherapy）. The retrieve time was from the establishment of the database to Jun. 2019. Data were extracted according to the Cochrane Collaboration Network Quality Evaluation Standards

the methodological quality of the included literature was assessed

and RevMan 5. 3 software was used to conduct on the outcome indicators（ Meta analysis）. RESULTS: Totally 17 literature were collected

including 1 609 patients. The results of meta-analysis showed that the short-term and long-term efficacy of the observation group was significantly higher than that of the control group

with statistically significant differences（ P<0. 05）. There was no significant difference in the incidence of adverse drug reactions between two groups（ P > 0. 05）. Cervical cancer detection markers such as squamous epithelial cell carcinoma antigen（ SCCAg） and cytokeratin 19 fragment antigen（ CYFRA21-1） in the observation group were significantly lower than those in the control group

and the differences were statistically significant（ P <0. 05）. The asymmetry between left and right funnel diagrams suggested that there was a certain publication bias in the included lioteratyre. CONCLUSIONS: The clinical efficacy of paclitaxel combined with carboplatin synchronized with radiotherapy and chemotherapy in the treatment of cervical cancer is significantly better than that of radiotherapy alone

which can improve the disease control rate

improve the quality of life of patients

and reduce gastrointestinal reactions

bone marrow suppression

radiation colitis

radiation cystitis and other adverse drug reactions. Due to the low quality of the randomized controlled trials included in this study

more rationally designed

large-sample

multicenter randomized controlled trials need to be carried out to verify its clinical effectiveness and safety

so as to provide safe and effective guidance for paclitaxel combined with carboplatin synchronized with radiotherapy and chemotherapy in the treatment of cervical cancer.