基于网络药理学的吴茱萸抗胃癌潜在有效成分及作用机制研究

韦颖; 王建; 任思陈; 杨玉雪; 王丹; 文建霞; 谢倩; 魏士长; 赵艳玲

doi:10.14009/j.issn.1672-2124.2020.01.002

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基于网络药理学的吴茱萸抗胃癌潜在有效成分及作用机制研究

本期特稿 | 更新时间：2022-08-15

- 基于网络药理学的吴茱萸抗胃癌潜在有效成分及作用机制研究
- Potential Active Components and Mechanism of Wuzhuyu in the Treatment of Gastric Cancer Based on Network Pharmacology
- 中国医院用药评价与分析 2020年20卷第1期页码：7-9
- 作者机构：
  
  1. 成都中医药大学药学院
  2. 中国人民解放军总医院第五医学中心药学部
- 作者简介：
- 基金信息：
  
  国家重点研发计划项目（No.2018YFC1704500）;1226工程卫生专业重大项目（No.AWS16J018）
- DOI：10.14009/j.issn.1672-2124.2020.01.002
  中图分类号： R285;R284.1
- 纸质出版日期：2020，
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[1]韦颖,王建,任思陈,杨玉雪,王丹,文建霞,谢倩,魏士长,赵艳玲.基于网络药理学的吴茱萸抗胃癌潜在有效成分及作用机制研究[J].中国医院用药评价与分析,2020,20(01):7-9+13.

WEI Ying, WANG Jian, REN Sichen, et al. Potential Active Components and Mechanism of Wuzhuyu in the Treatment of Gastric Cancer Based on Network Pharmacology[J]. 2020,20(1):7-9.
[1]韦颖,王建,任思陈,杨玉雪,王丹,文建霞,谢倩,魏士长,赵艳玲.基于网络药理学的吴茱萸抗胃癌潜在有效成分及作用机制研究[J].中国医院用药评价与分析,2020,20(01):7-9+13. DOI： 10.14009/j.issn.1672-2124.2020.01.002.

WEI Ying, WANG Jian, REN Sichen, et al. Potential Active Components and Mechanism of Wuzhuyu in the Treatment of Gastric Cancer Based on Network Pharmacology[J]. 2020,20(1):7-9. DOI： 10.14009/j.issn.1672-2124.2020.01.002.

摘要

目的:基于网络药理学方法

初步探讨吴茱萸抗胃癌潜在的有效成分及作用机制。方法:通过建立吴茱萸药物靶点数据集、胃癌靶点数据集

构建吴茱萸对胃癌的"成分-靶点-疾病"交互网络

并通过可视化分析、网络中各节点的拓扑参数分析

对各作用靶点进行基因本体（gene ontology

GO）富集分析及京都基因与基因组百科全书（Kyoto encyclopedia of genes and genomes

KEGG）通路分析

预测吴茱萸抗胃癌的作用机制。结果:筛选出3个吴茱萸主要活性成分

6个共同直接作用的蛋白靶点

8条通路参与吴茱萸治疗胃癌

包括p53信号通路、甲状腺激素信号通路和恶性肿瘤中的微小RNA等。结论:本研究通过网络药理学初步揭示了吴茱萸作用于胃癌的潜在成分及其调控网络

为其后续实验研究及临床应用提供了参考。

Abstract

OBJECTIVE: To preliminarily probe into the potential active components and mechanism of Wuzhuyu in the treatment of gastric cancer based on network pharmacology. METHODS: Through the establishment of target data of Wuzhuyu and gastric cancer

Ingredients-Target-Disease interactive network of Wuzhuyu in the treatment of gastric cancer was developed. Through visualization analysis and each node of topological parameters in the network

gene ontology（ GO） enrichment analysis and Kyoto encyclopedia of genes and genomes（ KEGG） pathway analysis were carried out for each target to predict the mechanism of Wuzhuyu in the treatment of gastric cancer. RESULTS: Three major active ingredients Wuzhuyu were screened out

six protein targets were directly affected

and eight pathways were involved in Wuzhuyu in the treatment of gastric cancer

including p53 signal pathway

thyroid hormone signal pathway and microRNA in malignant tumors. CONCLUSIONS: This study preliminarily reveals the potential ingredients of Wuzhuyu in the treatment of gastric cancer and the regulatory network through network pharmacology

which provides reference for the subsequent experimental research and clinical application.

关键词

吴茱萸胃癌网络药理学有效成分作用机制

Keywords

WuzhuyuGastric cancerNetwork pharmacologyActive ingredientsMechanism

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