Objective: To retrospectively analyze the adverse drug reactions (ADR) induced by fat soluble vitamins (Ⅰ) for injection in Chenzhou First People’s Hospital

and to probe into the general rules and characteristics of ADR

so as to reference for rational drug use in clinic. Methods: Clinical data of ADR induced by fat soluble vitamins (Ⅰ) for injection reported to the national ADR monitoring system in our hospital from Jan. 2010 to Dec. 2019 were retrospectively analyzed. Results: Forty-seven cases of ADR mainly occurred in children aged from 1 to 3 years

and the primary diseases were mainly digestive system diseases (55.32%). Forty-seven cases were given intravenous drip infusion

12 cases had off-label administration

and 9 cases had drug combination. Most of the 47 cases of ADR occurred within 30 min. The most frequently involved system/organ was the skin and its accessory damage

followed by the cardiovascular system damage

with common clinical manifestations of cyanosis and rash. The main type of ADR was general

and the prognosis was good. Conclusion: In order to reduce the incidence of ADR

fat soluble vitamins (Ⅰ) for injection should be used rationally in clinic to avoid off-label drug use and reduce the rate of drug combination. Attention should be paid to observe the clinical reaction of patients in the course of medication

timely detection of ADR and symptomatic treatment are necessary to avoid the occurrence of severe ADR.