Objective: To explore the PDCA cycle management in continuous improvement of the clinical application management of antibiotics in primary maternal and child health care hospitals

so as to enhance the clinical application management level of antibiotics and promote the rational drug application. Methods: Retrospective analysis was used to extract various regulatory indicators of antimicrobial management and clinical application from the hospital information system from 2015 to 2016. Problematic indicators and the causes were analyzed

the practical and feasible improvement management plans for the root causes were formulated and implemented in the clinical application management from 2017 to 2019. Intervention results were evaluated by comparing the changes in indicators before intervention (from 2015 to 2016) and after intervention (from 2017 to 2019). Results: After intervention

the proportion of consumption sum of antibiotics decreased from 12.19% to 6.71%

the application rate of antibiotics in outpatient (emergency) department decreased from 19.09% to 7.52%

the application rate of antibiotics for inpatients decreased from 55.09% to 38.36%

and the use intensity of antibiotics for inpatients decreased from 34.35 DDDs to 21.74 DDDs. The rate of microbiological samples sent by inpatients receiving antibiotics met the national requirements. Conclusion: The PDCA cycle management is effective in continuously improving the management of clinical application of antibiotics.