objective: To investigate the situation and regularity of adverse drug reaction (ADR) in children induced by ceftriaxone. Methods: Case report of ADR induced by ceftriaxone in Wanfang database from 1998 to 2018 were retrieved and extracted. Statistical analysis was conducted on age

gender

route of administration

original disease

occurrence time and recovery. Results: ADR induced by ceftriaxone was more common in children aged from 3 to 6 years (35.62%). Intravenous infusion (97.26%) was the main route of administration for ADR. Systems/organs involved were systemic damage (31.51%)

hepatobiliary system damage (21.92%)

abnormal platelets

bleeding and coagulation (12.33%). The main clinical manifestations were 19 cases of anaphylactic shock (26.03%)

the occurrence time of ADR was mostly 10 min after administration (23.29%). Anaphylactic shock mostly occurred within 5 min after administration (36.84%). There were 3 cases (4.11%) died. Conclusion: Clinical attention should be paid to ADR induced by ceftriaxone in adolescents and children to ensure medication safety.