Objective: To probe into the adverse drug reactions and causes of oral vancomycin in the treatment of Clostridium difficile infection. Methods: Combined with a case of rash induced by oral vancomycin in the treatment of Clostridium difficile infection

the literature on adverse drug reactions of oral vancomycin at home and abroad were retrieved and analyzed. Results: Oral administration of vancomycin might cause adverse drug reactions similar to those of intravenous administration

which was considered to be related to the absorption of vancomycin in the intestine. High-dose

long-term treatment

severe intestinal inflammatory disease

abnormal renal function

fasting and diarrhea are all high-risk factors for increased intestinal absorption of vancomycin. Conclusion: Pharmacists should be alert to the possible adverse drug reactions of oral vancomycin during clinical pharmaceutical care

and if necessary

blood drug concentration monitoring can be used to ensure the safety of clinical medication.