Objective: To probe into the pharmaceutical guidance role of clinical pharmacists in the treatment of one child with deep neck space infection complicated with septic shock. Methods: The clinical pharmacists participated into the consultation of a child with deep cervical space infection complicated with septic shock. According to the characteristics of the child’s disease condition

etiology and drug sensitivity results

combined with the bactericidal activity of antibiotics

PK/PD characteristics and tissue distribution

the medication regimen “vancomycin

imipenem/cilastatin

metronidazole sodium chloride injection and ceftriaxone sodium for injection” was adjusted to anti-infective treatment “penicillin G 100

000 U/kg each time

q4h ivgtt

linezolid 10 mg/kg each time

q8h ivgtt

combined with piperacillin sodium/tazobactam sodium 112.5 mg/kg each time

q8h ivgtt”. Results: The clinicians adopted the suggestions of consultation by clinical pharmacists

and the child had no significant fever after 8 d of continuous medication

and there was no fever after 10 d

and the vital signs were stable. The child was transferred to the department of pediatrics for piperacillin sodium/tazobactam sodium combined with linazolid treatment for 12 d. The entire treatment process lasted for 32 d

the infection symptoms of the child were basically controlled

and the child was discharged with continuous consolidation treatment. Conclusion: The participation of clinical pharmacists in optimizing anti-infective treatment regimens can promote the rational use of antibiotics and increase the effectiveness and success rate of treatment.