原发性肾病综合征患儿血清可溶性髓样细胞触发受体-1和可溶性尿激酶型纤溶酶原激活物受体水平的检测意义

王舒静; 童晓; 陈哲民

doi:10.13407/j.cnki.jpp.1672.108X.2020.12.002

您当前的位置：

首页 >

文章列表页 >

原发性肾病综合征患儿血清可溶性髓样细胞触发受体-1和可溶性尿激酶型纤溶酶原激活物受体水平的检测意义

本期目录 | 更新时间：2022-11-03

- 原发性肾病综合征患儿血清可溶性髓样细胞触发受体-1和可溶性尿激酶型纤溶酶原激活物受体水平的检测意义
- Clinical Significance of Serum Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Soluble Urokinase Type Plasminogen Activator Receptor in Children with Primary Nephrotic Syndrome
- 儿科药学杂志 2020年26卷第12期页码：4-7
- 作者机构：
  
  1. 江南大学附属医院，无锡市第三人民医院,江苏,无锡,214000
  2. 无锡市儿童医院,江苏,无锡,214000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672.108X.2020.12.002
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-12-10，
扫描看全文
王舒静, 童晓, 陈哲民. 原发性肾病综合征患儿血清可溶性髓样细胞触发受体-1和可溶性尿激酶型纤溶酶原激活物受体水平的检测意义[J]. 儿科药学杂志, 2020,26(12):4-7.

Wang Shujing, Tong Xiao, Chen Zhemin. Clinical Significance of Serum Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Soluble Urokinase Type Plasminogen Activator Receptor in Children with Primary Nephrotic Syndrome[J]. 2020,26(12):4-7.
王舒静, 童晓, 陈哲民. 原发性肾病综合征患儿血清可溶性髓样细胞触发受体-1和可溶性尿激酶型纤溶酶原激活物受体水平的检测意义[J]. 儿科药学杂志, 2020,26(12):4-7. DOI： 10.13407/j.cnki.jpp.1672.108X.2020.12.002.

Wang Shujing, Tong Xiao, Chen Zhemin. Clinical Significance of Serum Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Soluble Urokinase Type Plasminogen Activator Receptor in Children with Primary Nephrotic Syndrome[J]. 2020,26(12):4-7. DOI： 10.13407/j.cnki.jpp.1672.108X.2020.12.002.

摘要

目的：探讨原发性肾病综合征（PNS）患儿血清可溶性髓样细胞触发受体-1（sTREM-1）、可溶性尿激酶型纤溶酶原激活物受体（suPAR）水平与肾病病理类型和肾损伤的关系。方法：将124例在江南大学附属医院儿科接受治疗的PNS患儿作为观察组，同时选取30例健康儿童为对照组。根据病理类型，将观察组分为局灶性节段性肾小球硬化（FSGS）组35例、系膜增生性肾小球肾炎（MsPGN）组41例、膜性肾病（MN）组27例、肾小球微小病变型（MCD）组21例；根据有无急性肾损伤，将观察组分为肾损伤组33例和非肾损伤组91例。检测受试者血清sTREM-1、suPAR水平，并分析其与肾病病理类型和肾脏损伤的关系。结果：观察组sTREM-1、suPAR、总胆固醇（TC）、三酰甘油（TG）、血肌酐（Scr）、尿酸（UA）、24 h尿蛋白（24hUp）、尿N-乙酰-β-氨基葡萄糖苷酶（uNAG）、尿微球蛋白（uβ2-MG）水平高于对照组，血清蛋白（ALB）水平低于对照组（P均<0.05）。肾损伤组血清sTREM-1、suPAR水平高于非肾损伤组（P均<0.05）；MsPGN组、MN组、MCD组血清sTREM-1、suPAR水平比较差异无统计学意义（P均>0.05），而均低于FSGS组（P均<0.05）。血清sTREM-1、suPAR与TC、TG、24hUp、uNAG及uβ2-MG呈正相关，而与ALB呈负相关（P均<0.05）。结论：PNS患儿血清sTREM-1、suPAR水平显著上升，且可在一定程度上反映PNS病理类型和肾功能。

Abstract

Objective: To investigate the correlation between serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and soluble urokinase type plasminogen activator receptor (suPAR) in children with primary nephrotic syndrome (PNS) and pathological types and renal damage. Methods: A total of 124 children with PNS admitted into Affiliated Hospital of Jiangnan University were extracted as the observation group

while 30 healthy children were selected as the control group. According to pathological types

patients in the observation group were divided into the focal segmental glomerulosclerosis group (FSGS group

n=35)

the mesangial proliferative glomerulonephritis group (MsPGN group

n=41)

the membranous nephropathy group (MN group

n=27) and the glomerular microlesion group (MCD group

n=21). According to the presence or absence of acute renal injury

patients in the observation group were divided into the renal injury group (n=33) and the non-renal injury group (n=91). The serum levels of sTREM-1 and suPAR were measured

and the correlation with pathological types of PNS and renal injury was analyzed. Results: Levels of sTREM-1

suPAR

total cholesterol (TC)

triglyceride (TG)

serum creatinine (Scr)

uric acid (UA)

24-hour urinary protein (24hUP)

urinary n-acetyl-β-glucosaminidase (uNAG)

urinary microglobulin (uβ2-MG) in the observation group were higher than those in the control group (P<0.05)

and serum protein (ALB) were lower than those in the control group (P<0.05). Serum levels of sTREM-1 and suPAR in the renal injury group were higher than those in the non-renal injury group (P<0.05); there was no statistically significant difference in serum levels of sTREM-1

suPAR among MsPGN group

MN group and MCD group (P>0.05)

which were lower than those of the FSGS group (P<0.05). Serum levels of sTREM-1 and suPAR were positively correlated with TC

24hUP

uNAG and uβ2-MG (P<0.05)

and negatively correlated with ALB (P<0.05). Conclusion: The serum levels of sTREM-1

suPAR in children with PNS increased significantly

which could reflect the pathological types of PNS and renal function to a certain extent.

关键词

原发性肾病综合征可溶性髓样细胞触发受体-1可溶性尿激酶型纤溶酶原激活物受体急性肾损伤

Keywords

primary nephrotic syndromesoluble triggering receptor expressed on myeloid cells-1soluble urokinase type plasminogen activator receptoracute renal injury

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

利妥昔单抗治疗儿童原发性肾病综合征的严重药物不良事件分析