Objective: To study the anti-inflammatory

anti-allergic and anti-pruritic effects of chloramphenicol prednisone liniment in animals

so as to provide reference for clinical application. Methods: Anti-inflammatory effects of chloramphenicol prednisone liniment were observed in mice with xylene-induced ear swelling. Anti-allergic effects of chloramphenicol prednisone liniment were observed in mice with delayed-type hypersensitivity induced by 2

4-dinitrochlorobenzene (DNCB). Anti-pruritus effects of chloramphenicol prednisone liniment were observed in mice with skin allergic itching induced by 4-aminopyridine (4-AP). Results: Compared with the model control group

chloramphenicol prednisone liniment could significantly alleviate xylene-induced ear swelling in mice and reduce DNCB-induced allergic reaction in mice. Chloramphenicol prednisone liniment could reduce the number of carcasses induced by 4-AP in mice

prolong pruritus latency and shorten the duration of pruritus. Conclusion: Chloramphenicol prednisone liniment has significant anti-inflammatory

anti-allergic and anti-pruritus effects.