Objective: To evaluate the efficacy and safety of 2% crisaborole ointment in the treatment of mild to moderate atopic dermatitis in children. Methods: A total of 84 children with mild to moderate atopic dermatitis were randomly divided into 47 cases in the treatment group and 37 cases in the control group

respectively treated with 2% crisaborole ointment+emollients and emollients alone for 4 weeks. The effective rate and degree of pruritus improvement in two groups were compared. Results: The effective rate of treatment group and control group were respectively 72. 34% and 27. 03%

with statistically significant difference (P<0. 01). The score of pruritus in the treatment group was significantly improved compared with the control group

with a particular predominance of improvement in nocturnal pruritus and dynamic pruritus score. The improvement rate of pruritus in the treatment group was 63. 83%

significantly higher than 13. 51% in the control group. Adverse drug reactions were rare

only transient local stimulation. Conclusion: 2% crisaborole ointment is safe and effective in the treatment of mild to moderate atopic dermatitis in children.