To analyze the medication status of adolescents with depression in Hangzhou through real-world data

so as to provide reference for clinical treatment. Methods: Drug use data of adolescents with depression from 12 hospitals in Hangzhou from 2018 to 2020 were collected

and the basic information

prescription data and medication regimen of patients were statistically analyzed. Results: From 2018 to 2020

there was a year-on-year increase in the number of adolescent depression cases in Hangzhou. The average age of patients decreased over this period

and the number of female patients was larger than that of males. The most commonly prescribed medications included first- and second-line antidepressants

antipsychotic drugs

sedatives and hypnotics

with sertraline being the most frequently used. Predominant medication regimen was the use of second-line antidepressants as monotherapy. Drug combination of first- and second-line antidepressants with antipsychotic drugs showed significant increase in usage ( with a compound annual growth rate of 18. 66%). The rate of drug combination in bipolar affective disorder group was higher (P<0. 05). Conclusion: The number of adolescents with depression in Hangzhou is on the rise

with a trend towards younger patients. Clinical treatment primarily involves second-line medication

and treatment selections are aligned with patient symptoms and guidelines

indicating a rational approach to medication.