Objective: To probe into the current status of drug use in outpatient and emergency prescriptions of children of cardiovascular specialty in Beijing Children’s Hospital

Capital Medical University

so as to provide reference for clinical rational drug use. Methods: Retrospective analysis was used to collect the irrational positive outpatient and emergency prescriptions in cardiology department in 2021 after the daily review by the software of rational drug use. After the review by pharmacists and clinicians

the true positive irrational prescriptions were analyzed statistically by Excel software. Results: A total of 84

821 outpatient and emergency prescriptions in cardiology department of our hospital in 2021 were collected

and 335 irrational positive prescriptions were reviewed by software of rational drug use

including 360 drug information entries

of which 169 ( 46. 94%) were inappropriate indications

134 (37. 22%) were improper usage and dosage

24 (6. 67%) were inappropriate repeated drug use

17 (4. 72%) were irrational drug selection

10 (2. 78%) were improper drug interactions

and 6 (1. 67%) were inappropriate route of administration. After the positive irrational prescriptions screened by the joint clinical pharmacist/ clinician pre-review system for pediatric cardiovascular specialty

166 true positive irrational prescriptions were determined

accounting for 0. 20% of the sampled prescriptions

involving a total of 171 irrational medication entries

including 88 ( 51. 46%) inappropriate indications

63 ( 36. 84%) improper usage and dosage

17 (9. 94%) improper drug selection

2 (1. 17%) repeat drug use

and 1 (0. 59%) inappropriate route of administration. According to Pareto chart analysis

inappropriate indications and 2 kinds of improper usage and dosage were the main factors

improper drug selection was the secondary factor

3 kinds of improper usage and dosage

1 kind of improper usage and dosage

repeated drug use and inappropriate route of administration were the general factors. Among the 62 drugs involved in irrational prescription

there were few problems in professional cardiovascular medicine. Conclusion: There are few cases of irrational drug use in outpatient and emergency department of children of cardiovascular specialty

and the existing irrational drug use situation mainly manifest as inappropriate indications and improper usage and dosage. In order to further optimize rational drug use in outpatient and emergency departments of children of cardiovascular specialty

on the basis of real-time prescription pre-review

the standardized management of off-label drug use and refined system rules of usage and dosage are constantly improved

and key pharmaceutical intervention is conducted for the existing main drug use problems so as to make continuous improvement and optimization.