Objective: To probe into the effects of contrast medium on renal function of neonates in computed tomography (CT) and magnetic resonance (MR) enhanced examination and the correlation between age and renal function indicators. Methods: Clinical data of 81 neonates received CT/ MR examination in the First Affiliated Hospital of Zhengzhou University from Jan. 2017 to May 2021 were retrospectively analyzed. All patients were divided into 38 cases in the contrast group and 43 cases in the control group according to whether enhancement test was performed. The general data

age at the time of examination

body mass

age

serum creatinine (Scr) and glomerular filtration rate ( GFR) at different time points of two groups were collected and compared. The correlation between neonatal age and renal function was analyzed. Results: There was no significant difference in gender

premature delivery

delivery method

examination method

sedative application and primary disease distribution between two groups ( P > 0. 05). There was no statistically significant difference between the age at the time of examination and body mass

age

Scr and GFR at different time points (P>0. 05). Spearman correlation analysis showed that Scr was negatively correlated with age ( r = - 0. 606

P < 0. 01)

GFR was positively correlated with age (r = 0. 508

P<0. 01). Conclusion: The application of contrast medium in CT/ MR enhanced examination has no significant effect on renal function of neonates. Neonatal age was negatively correlated with Scr levels and positively correlated with GFR levels.