Objective: To understand the composition and use of multiple drug-resistant bacteria in neonatal department of a hospital

and to guide the rational use of antibiotics in clinic. Methods: The bacterial surveillance results of multiple drug resistance infection in 154 newborns in the department of neonatal department of a hospital from 2019 to 2021 were analyzed from the detection rate of multiple drug resistance

the general condition of newborns

the source distribution of samples

and the composition of multiple drug resistant strains. Results: A total of 166 strains of multiple drug-resistant bacteria were detected from the 154 neonates from 2019 to 2021

and the top 3 sources of samples were sputum

blood

and bronchial secretions. The incidence of multiple drug resistance infection was higher in premature and low birth weight infants

and the main multi-drug resistant bacteria detected were producing ESBLs Escherichia coli and Klebsiella pneumoniae. The detection rate showed downward trend in general. The drug sensitivity results showed that the resistance rate of Escherichia coli and Klebsiella pneumoniae to cefuroxime and ceftriaxone was 100%

and the sensitive rate to ertapenem and imipenem was 100%. Conclusion: The main pathogens infected by multiple drug-resistant bacteria in neonatal department of the hospital are Gram-negative bacteria and are resistant to most antibiotics.