Objective: To explore the factors affecting the steady-state plasma concentration of lacosamide (LCM) in children with epilepsy in Xinjiang

and to establish the reference range of steady-state plasma concentration of LCM

so as to provide theoretical basis for clinical individualized drug use. Methods: The serum drug concentration was collected and measured in 313 children with epilepsy in Xinjiang who regularly took LCM and reached steady-state blood concentration

and the effects of age

gender

ethnicity

dosage and combined use on the serum concentration of LCM were analyzed

and the reference range of steady-state serum concentration of LCM was preliminarily established. Results: There was no significant difference in LCM concentration-dose ratio (CDR) values among children with epilepsy of different genders and ethnic groups (P>0. 05). The dosage of the 4 to 6 age group was significantly higher than that of the 7 to 14 age group

and the CDR results of the 7 to 14 age group were significantly higher than that of the 4 to 6 age group (all P< 0. 01). The concentration results of the children in the LCM single drug group were significantly lower than those of the LCM combined with other antiepileptic drugs groups (all P<0. 05). The reference range of steady-state blood concentration of LCM in this study was 2. 02-14. 47 μg/ mL. Conclusion: During the clinical use of LCM to control and treat epilepsy in children

it is necessary to monitor the therapeutic drug of LCM in order to adjust its dosage in time and better control epileptic seizures.