Objective: To investigate the changes of hepatitis B core antibody (HBcAb) in newborns after intravenous immunoglobulin (IVIG). Methods: Retrospective research method was conducted in this study to collect medical records of newborns who had IVIG in our hospital from 2019 to 2020

and the changes of HBcAb before and after using IVIG were compared. Results: Among 43 hospitalized children treated with IVIG

5 children were HBcAb positive before IVIG treatment; HBcAb was still negative in 10 children after IVIG treatment; HBcAb was positive in 18 children after IVIG;10 children were not retested for hepatitis B after IVIG

so the changes of HBcAb were unknown. Conclusion: Infusion of IVIG can increase the level of HBcAb in neonates

which suggests that it is of great significance to eliminate passive transfer of antibodies in neonates with IVIG.