Objective: To explore the safety of painless anesthesia of dexmedetomidine combined with esketamine during fiberoptic bronchoscopy in children. If sufentanil is added

whether it can reduce the dosage of esketamine and reduce the incidence of adverse reactions. Methods: A total of 40 children who were scheduled to undergo fiberoptic bronchoscopy in our hospital were randomized into 2 groups in average

dexmedetomidine 1 μg/ kg + esketamine 1 mg/ kg (group E) and dexmedetomidine 1 μg/ kg + esketamine 1 mg/ kg + sufentanil 0. 1 μg/ kg (group S). The vital signs including heart rate (HR)

mean arterial pressure (MAP)

pulse oxyhemoglobin saturation (SpO2 ) and adverse reactions at basic (T0 )

after induction (T1 )

the fiberoptic bronchoscopy passing through the glottis (T2 )

the scope passing through the carina (T3 )

and 10 min after completion (T4 ) were observed and compared between the two groups. Results: The HR of T2 and T3 in the group E was significantly faster than that of T1 (all P<0. 05)

and there was no significant difference in MAP and SpO2 at T0 to T4 (all P>0. 05). There was no significant difference in HR

MAP and SpO2 at T0 to T4 between the two groups (all P>0. 05). There was no significant difference in the incidence of hyoxemia and drug dosage of esketamine between the two groups (all P>0. 05). Conclusion: Dexmedetomidine combined with esketamine can be used for pediatric fiberoptic bronchoscopy

but the additional use of sufentanil can not reduce the dosage of esketamine

nor the incidence of adverse reactions like hyoxemia. Thus

it’s no need of adding sufentanil.