Objective: To explore the clinical characteristics

treatment and prognosis of neonatal influenza A. Methods: Clinical data of 25 hospitalized neonates diagnosed with influenza A in Neonatology Department of Hunan Children’s Hospital from January 2018 to January 2020 were analyzed retrospectively. The clinical characteristics

auxiliary examinations

treatment process and outcomes of the neonates were analyzed. Results: Among the 25 cases

17 were male and 8 were female. There were 16 full-term infants and 9 premature infants

among which 7 were late premature infants. Eighteen cases occurred in winter and spring

and 7 cases occurred in summer. Twelve cases had close contact with family members with symptoms of “cold” before ill. Clinical manifestations included cough in 17 cases

fever in 17 cases

dyspnea in 10 cases

nasal congestion in 12 cases

runny nose in 3 cases

and apnea in 1 case. All the 25 cases tested positive for influenza A virus antigen

6 cases tested positive for respiratory syncytial virus at the same time

and sputum bacteria culture was positive in 17 cases. Sixteen cases were treated with oseltamivir and 2 cases with peramivir. Twenty-four cases were cured and discharged

and 1 case died (a premature infant). Conclusion: The symptoms of influenza A infection in neonates are not typical

the incidence is usually high in winter and summer

and the prognosis is generally good

but the premature infants should be alert to serious complications and poor prognosis.