Objective: To understand the irrational use of antineoplastic drugs in intravenous admixture service center in 2018 and 2019

compare the change of the incidence of irrational prescriptions in two years after pharmacist intervention

provide support for finding more effective intervention mechanism to ensure the safety of drug using in cancer patients. Methods: The total number of anti-tumor drug prescriptions was 3

796

including 302 irrational prescription. Referring to the relevant information

χ² test was used to classify the irrational prescription of antineoplastic drugs in two years. Result: Error type ware high or weight error

wrong drug dosage

wrong medication time

wrong drug concentration

incompatibility

repeated use of drugs

solvent error

medical order input error

wrong route of drug use. The incidence of irrational drug use did not decreased significantly before and after pharmacist intervention (χ²=0.865

P>0.05). Conclusion: Due to the cytotoxicity of chemotherapeutic drugs

there are high risks in use

and the accuracy of doctor’s order review is also required to be higher

although the short-term intervention effect of pharmacists is not statistically obvious. Although the effect of intervention was not statistically significant

in order to ensure the safety of children with cancer in the process of chemotherapy

pharmacists need to sum up experience in the work to update the prescription review measures and intervention methods.