Objective: To study the application value of Huaiqihuang granules in children with mild persistent asthma. Methods: A prospective

randomized

controlled study method was used to collect 60 cases of children with mild persistent asthma who attended the pediatric clinic of our hospital. They were divided into two groups according to the random number table method

including the Huaiqihuang group ( treated with inhaled corticosteroids + Huaiqihuang granules) and the control group ( treated with inhaled corticosteroids)

30 cases for each. Comparing the clinical evaluation indicators and child asthma control Test (C-ACT) scores at 1

3 and 6 months after treatment

and monitoring the changes of IgE

IL-4

IL-17

exhaled nitric oxide (FeNO)

and impulsed pulmonary function (IOS) before and after treatment. Results: After 3

6 months of treatment in the two groups

the clinical symptoms of the Huaiqihuang group were significantly improved compared with those of the control group

and the C-ACT was the highest (P<0. 05). After 3 months of treatment

the levels of IgE

IL-4

IL-17

FeNO

total airway resistance

peripheral elastic resistance and resonance frequency in the two groups were significantly lower than before treatment

with the Huaiqihuang group significantly lower than control group (P<0. 05). There was no significant difference in central airway resistance in two groups compared with that before the treatment (P>0. 05). Conclusion: Huaiqihuang granules combined with inhaled corticosteroids has a better therapeutic effect on asthma

and can reduce airway inflammation

lower the level of eosinophils and improve small airway function by down-regulating IgE

IL-4

and IL-17.