2岁以下儿童肝移植应用伏立康唑的药学监护

王维娜; 程晟; 卫红涛; 沈素

doi:10.13407/j.cnki.jpp.1672-108X.2023.01.004

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2岁以下儿童肝移植应用伏立康唑的药学监护

论著 | 更新时间：2023-04-14

- 2岁以下儿童肝移植应用伏立康唑的药学监护
- Analysis of Pharmaceutical Care on the Use of Voriconazole in Pediatric Liver Transplantation Patients Younger Than 2 Years of Age
- 儿科药学杂志 2023年29卷第1期页码：11-14
- 作者机构：
  
  首都医科大学附属北京友谊医院,北京,100050
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2023.01.004
  中图分类号：
- 纸质出版日期：2023，
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王维娜, 程晟, 卫红涛, 等. 2岁以下儿童肝移植应用伏立康唑的药学监护[J]. 儿科药学杂志, 2023,29(1):11-14.

Wang Weina, Cheng Sheng, Wei Hongtao, et al. Analysis of Pharmaceutical Care on the Use of Voriconazole in Pediatric Liver Transplantation Patients Younger Than 2 Years of Age[J]. 2023,29(1):11-14.
王维娜, 程晟, 卫红涛, 等. 2岁以下儿童肝移植应用伏立康唑的药学监护[J]. 儿科药学杂志, 2023,29(1):11-14. DOI： 10.13407/j.cnki.jpp.1672-108X.2023.01.004.

Wang Weina, Cheng Sheng, Wei Hongtao, et al. Analysis of Pharmaceutical Care on the Use of Voriconazole in Pediatric Liver Transplantation Patients Younger Than 2 Years of Age[J]. 2023,29(1):11-14. DOI： 10.13407/j.cnki.jpp.1672-108X.2023.01.004.

摘要

目的:通过对2 岁以下肝移植受者伏立康唑的应用现状进行回顾性分析

为临床药师深入开展药学监护提供有效的切入点和工作思路。方法:对2017-2019 年某院2 岁以下肝移植患儿应用伏立康唑的情况进行调查和分析。结果:126 例患儿使用伏立康唑预防或治疗侵袭性真菌病

初始剂量为4~6 mg/ kg

每日2 次

不良反应发生率为0. 79%。96 例治疗性用药患儿的总有效率为96. 8%

30 例预防性用药患儿的预防成功率为86. 67%。结论:临床药师可以根据循证证据从初始用药剂量、血药浓度监测、用药剂量调整、重点指标的综合评估等方面加强药学监护

提供用药建议

并开展科研工作。

Abstract

Objective: To provide effective points and ideas of pharmaceutical care for clinical pharmacists through retrospective analysis on the use of voriconazole in liver transplantation recipients under 2 years old. Methods: The application of voriconazole in liver transplantation recipients under 2 years old from 2017 to 2019 was investigated and analyzed. Results: In 126 patients

voriconazole was used to prevent or treat invasive fungal disease. The initial dose of voriconazole was 4-6 mg/ kg

twice a day

with incidence of adverse reactions of 0. 79%. The total therapeutic effective rate in 96 patients with therapeutic administration was 96. 8%

and the success rate of prevention in 30 patients with prophylactic administration was 86. 67%. Conclusion: Clinical pharmacists can provide evidence-based pharmaceutical suggestions and scientific propaganda by carrying out pharmaceutical care from initial dosage

blood concentration monitoring

dosage adjustment and comprehensive evaluation of key indicators

and scientific research.

关键词

伏立康唑儿童肝移植临床药师药学监护

Keywords

oriconazolechildrenliver transplantationclinical pharmacistpharmaceutical care

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