Objective: To investigate the pharmacokinetics of cyclosporine (CsA) in rats with ulcerative colitis (UC) induced by sodium glucan sulfate (DSS). Methods: Twelve rats were randomly divided into two groups: the control group (normal feeding) and the UC group (5% DSS free drinking for 7 days to induce the UC model). On the 8th day

rats in both groups were given CsA 15 mg/ kg by gavage. Blood collection was performed before and after the administration

the plasma concentration was detected and the main pharmacokinetic parameters were compared between groups. Results: Compared with the control group

the exposure intensity of CsA in the UC group was significantly increased

the area under the curve (AUC) was increased significantly by 35. 69%

the half-life was extended by 34. 94%

the retention time (MRT) was also extended by 23. 17%

and the drug elimination rate was decrease significantly by 28. 00% (P<0. 05). Conclusion: The pharmacokinetics of CsA in rats can be changed by UC disease status. Metabolism decline

half-life extension

and increased exposure intensity

may be related to the increased CsA absorption. This study provides references for the safe use of CsA in clinical.