Objective: To explore the effects of common intestinal flora and its metabolites in the progression of allergic asthma (AA) in children. Methods: Eighty children with acute attack of AA admitted into outpatient

emergency and inpatient departments of the hospital from 2019 to 2021 were selected as the research subjects. All children were divided into the mild group

moderate group and severe group

according to the grading of acute attack of AA condition in Pediatrics (9th Edition). The baseline data

common intestinal flora and its metabolites of acute attack of AA in children with different disease degrees were compared. Correlation between common intestinal flora and its metabolites and the severity of children with acute attack of AA was emphatically analyzed. Results: Among 80 children with acute attack of AA

28 cases were mild

34 cases were moderate and 18 cases were severe. The levels of Lactobacillus

Bifidobacterium

acetic acid and butyric acid were the highest in the mild group

followed by the moderate group and the severe group

with statistically significant differences (P<0.05). The levels of Escherichia coli and lipopolysaccharide were the highest in the severe group

followed by the moderate group and the mild group

with statistically significant differences (P<0.05). Results of Kendall’s tau-b correlation test showed that the grade of acute attack of AA was negatively correlated with the levels of Lactobacillus

Bifidobacterium

acetic acid and butyric acid of short-chain fatty acids (r<0

P<0.05)

and positively correlated with the levels of E. coli and lipopolysaccharide (r>0

P<0.05). Results of ordered regression analysis showed that the high levels of Lactobacillus

Bifidobacterium

acetic acid and butyric acid were the protective factors for the grading of AA (OR<1

P<0.05)

and the high levels of Escherichia coli and lipopolysaccharide were the risk factors (OR>1

P<0.05). Results of decision curve showed that the net benefit rate of joint assessing the severity grading was more than 0 with Lactobacillus

Bifidobacterium and E. coli within the high-risk threshold range from 0.0 to 1.0

and was more than 0 with acetic acid

butyric acid and lipopolysaccharide

which had clinical significance. Conclusion: Lactobacillus

Bifidobacterium

E. coli and its metabolites acetic acid

butyric acid and lipopolysaccharide are correlated with the severity of acute attack of AA in children

and may play a role in the progression of AA.