Objective: To investigate the effects of triple therapy combined with synbiotics in eradication of Helicobacter pylori (Hp). Methods: CNKI

Wanfang

VIP

EMBase

PubMed and the Cochrane Library were retrieved to collect the randomized controlled trial of triple therapy combined with synbiotics in the treatment of Hp. The retrieval time was from the establishment of the database to Mar. 2020. After literature screening

quality evaluation and data extraction

Meta-analysis was performed by using RevMan 5.3 software. Results: A total of 4 studies were enrolled

including 354 patients. Meta-analysis showed that synbiotics supplementation could improve eradication rate of Hp (OR=2.63

95%CI from 1.57 to 4.40

P<0.01). Analysis was further performed by dividing patients into two subgroups of adults and children by age

which showed that the eradication rate of Hp could be improved both in children group (OR=2.38

95%CI from 1.32 to 4.26

P<0.01) and adult group (OR=3.68

95%CI from 1.22 to 11.15

P<0.05) by synbiotics supplementation. Conclusion: Synbiotics

as the adjunct treatment for triple therapy

can improve the eradication rate of Hp. However

the sample size of the study was small

the conclusions need to be verified by large-scale high-quality studies.