1例肝移植术后耐碳青霉烯大肠埃希菌致血流和腹腔感染患儿的药学监护

金海荣; 宋燕青; 梁晓宇; 马洁

doi:10.13407/j.cnki.jpp.1672-108X.2022.12.003

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1例肝移植术后耐碳青霉烯大肠埃希菌致血流和腹腔感染患儿的药学监护

论著 | 更新时间：2023-04-16

- 1例肝移植术后耐碳青霉烯大肠埃希菌致血流和腹腔感染患儿的药学监护
- Pharmaceutical Care for a Child with Bloodstream and Abdominal Infection Induced by Carbapenem Resistant Escherichia Coli after Liver Transplantation
- 儿科药学杂志 2022年28卷第12期页码：7-10
- 作者机构：
  
  吉林大学第一医院,吉林,长春,130021
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2022.12.003
  中图分类号：
- 纸质出版日期：2022，
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金海荣, 宋燕青, 梁晓宇, 等. 1例肝移植术后耐碳青霉烯大肠埃希菌致血流和腹腔感染患儿的药学监护[J]. 儿科药学杂志, 2022,28(12):7-10.

Jin Hairong, Song Yanqing, Liang Xiaoyu, et al. Pharmaceutical Care for a Child with Bloodstream and Abdominal Infection Induced by Carbapenem Resistant Escherichia Coli after Liver Transplantation[J]. 2022,28(12):7-10.
金海荣, 宋燕青, 梁晓宇, 等. 1例肝移植术后耐碳青霉烯大肠埃希菌致血流和腹腔感染患儿的药学监护[J]. 儿科药学杂志, 2022,28(12):7-10. DOI： 10.13407/j.cnki.jpp.1672-108X.2022.12.003.

Jin Hairong, Song Yanqing, Liang Xiaoyu, et al. Pharmaceutical Care for a Child with Bloodstream and Abdominal Infection Induced by Carbapenem Resistant Escherichia Coli after Liver Transplantation[J]. 2022,28(12):7-10. DOI： 10.13407/j.cnki.jpp.1672-108X.2022.12.003.

摘要

目的：探讨临床药师在肝移植术后患儿抗感染治疗中的作用。方法：1例8个月患儿肝移植术后合并耐碳青酶烯大肠埃希菌致血流和腹腔感染，经临床药师多次会诊，优化抗感染药物治疗方案，并结合患儿情况，提出美罗培南大剂量用药且延长时间泵入的建议，根据患儿病情变化加用阿米卡星、复方磺胺甲噁唑治疗，同时规避药物相互作用和关注药物不良反应。结果：抗感染治疗有效，患儿治愈出院。结论：临床药师发挥专长，协助医师制定治疗方案，对特殊人群的抗感染治疗进行密切监护，提高了临床药物治疗的有效性和安全性。

Abstract

Objective: To probe into the role of clinical pharmacists in anti-infective therapy of a child after liver transplantation. Method: For an 8-month child with bloodstream and abdominal infection induced by carbapenem resistant Escherichia coli after liver transplantation

clinical pharmacists optimized the anti-infective therapy regimen after several times of consultations

suggested high-dose meropenem with prolonged pumping time

and added amikacin and compound sulfamethoxazole according to the child’s condition

while avoiding drug interactions and paying attention to adverse drug reactions. Results: The anti-infective therapy was effective and the child was cured and discharged. Conclusion: Clinical pharmacists give full play to their expertise to assist clinicians in formulating treatment regimens and closely monitor the anti-infective therapy in special populations

thus improving the efficacy and safety of clinical drug therapy.

关键词

肝移植抗感染治疗临床药师药学监护

Keywords

liver transplantationanti-infective therapyclinical pharmacistspharmaceutical care

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