13种儿科常用抗菌药物与小儿电解质补给注射液配伍稳定性

魏霞; 李英; 程青; 卢庆红; 王晓玲

doi:10.13407/j.cnki.jpp.1672-108X.2022.11.006

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13种儿科常用抗菌药物与小儿电解质补给注射液配伍稳定性

论著 | 更新时间：2023-04-14

- 13种儿科常用抗菌药物与小儿电解质补给注射液配伍稳定性
- Compatible Stability of 13 Kinds of Commonly Used Antibiotics Injections and Pediatric Electrolyte Supplements Injection
- 儿科药学杂志 2022年28卷第11期页码：21-25
- 作者机构：
  
  1. 江西省儿童医院,南昌,360000
  2. 国家儿童医学中心，首都医科大学附属北京儿童医院,北京,100045
- 作者简介：
- 基金信息：
  
  北京儿童健康基金会药学学科建设专项子项目,编号BCHF2020KY001
- DOI：10.13407/j.cnki.jpp.1672-108X.2022.11.006
  中图分类号：
- 纸质出版日期：2022，
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魏霞, 李英, 程青, 等. 13种儿科常用抗菌药物与小儿电解质补给注射液配伍稳定性[J]. 儿科药学杂志, 2022,28(11):21-25.

Wei Xia, Li Ying, Cheng Qing, et al. Compatible Stability of 13 Kinds of Commonly Used Antibiotics Injections and Pediatric Electrolyte Supplements Injection[J]. 2022,28(11):21-25.
魏霞, 李英, 程青, 等. 13种儿科常用抗菌药物与小儿电解质补给注射液配伍稳定性[J]. 儿科药学杂志, 2022,28(11):21-25. DOI： 10.13407/j.cnki.jpp.1672-108X.2022.11.006.

Wei Xia, Li Ying, Cheng Qing, et al. Compatible Stability of 13 Kinds of Commonly Used Antibiotics Injections and Pediatric Electrolyte Supplements Injection[J]. 2022,28(11):21-25. DOI： 10.13407/j.cnki.jpp.1672-108X.2022.11.006.

摘要

目的：探讨13种儿科常用抗菌药物与小儿电解质补给注射液的配伍稳定性。方法：模拟临床用药，考察13种儿科常用抗菌药物与小儿电解质补给注射液配伍后的外观、性状、pH和主要成分相对含量变化情况。结果：头孢呋辛钠、头孢他啶、头孢曲松钠、头孢美唑钠、哌拉西林钠/他唑巴坦钠、拉氧头孢钠、亚胺培南/西司他丁钠、美罗培南与小儿电解质补给注射液配伍后0~4 h内其外观、可见异物、pH和主要成分相对含量均无明显变化；万古霉素、阿奇霉素、阿米卡星、伏立康唑、头孢哌酮钠/舒巴坦钠与小儿电解质补给注射液配伍后0~8 h内其外观、性状、pH和主要成分相对含量均无明显变化。结论：头孢呋辛钠、头孢他啶、头孢曲松钠、头孢美唑钠、哌拉西林钠/他唑巴坦钠、拉氧头孢钠、亚胺培南/西司他丁钠、美罗培南、万古霉素、阿奇霉素、阿米卡星、伏立康唑、头孢哌酮钠/舒巴坦钠与小儿电解质补给注射液配伍良好

Abstract

Objective: To probe into the compatible stability of 13 kinds of commonly used antibiotics injections and pediatric electrolyte supplements injection. Methods: The appearance

characteristics

pH and relative content of main components of 13 kinds of commonly used pediatric antibiotics combined with pediatric electrolyte supplement injection were investigated by simulating clinical medication. Results: Cefuoxime sodium

ceftazidime

ceftriaxone sodium

cefmetazole sodium

piperacillin sodium/tazobactam sodium

latamoxef sodium

imipenem/cilastatin sodium and meropenem had no significant changes in appearance

characteristics

pH and relative content of main components within 4 h after the combination with pediatric electrolyte supplements injection. Vancomycin

azithromycin

amikacin

voriconazole

cefoperazone sodium/sulbactam sodium had no significant changes in appearance

characteristics

pH and relative content of main components within 8 h after the combination with pediatric electrolyte supplements injection. Conclusion: Cefuroxime sodium

ceftazidime

ceftriaxone sodium

cefmetazole sodium

piperacillin sodium/tazobactam sodium

laoxycef sodium

imipenem/cilastatin sodium

meropenem

vancomycin

azithromycin

amikacin

voriconazole

cefoperazone sodium/sulbactam sodium are well compatible with pediatric electrolyte supplements injection

关键词

小儿电解质补给注射液抗菌药物配伍稳定性

Keywords

pediatric electrolyte supplements injectionantibioticscompatible stability

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