Objective: To probe into the medication cognition of children’s guardians during the application of acetaminophen (APAP) and analyze the influencing factors

so as to promote rational drug application in children. Methods: Electronic questionnaire was used for investigation. Results: The identification of drugs containing APAP showed that 24.49% of the guardians did not know whether there was APAP in the 6 listed drugs

and no guardian recognized all the drugs containing APAP. The results of APAP usage and dosage survey showed that 37.24% of the guardians did not correctly select the minimum interval of 4 h between APAP administration

and 48.47% of the guardians responded incorrectly to the maximum of 4 times for APAP administration in 24 h. According to the judgment of related statements on the clinical application of APAP

32.65% of the guardians thought that there was no need to worry about the medication safety of APAP

and 42.35% of the guardians thought that APAP would not appear in Chinese patent medicine. The analysis of influencing factors of guardian score showed that the guardian score in urban area was higher than that in rural area (P<0.05)

the score of medical staff was higher than that of other occupation (P<0.01). Conclusion: Medical staff should give full play to their professional advantages

guide the guardians to use drugs

standardize the drug use behaviors

and reduce the occurrence of adverse drug reactions