Objective: To systematically evaluate the efficacy of gamma globulin combined with glucocorticoid and glucocorticoid alone in the treatment of children with abdominal Henoch-Schönlein purpura. Methods: PubMed

EMBase

the Cochrane Library

CBM

CNKI and Wanfang database were retrieved to collect the randomized controlled trails (RCT) and non-RCT of gamma globulin combined with glucocorticoid and glucocorticoid alone in the treatment of children with abdominal Henoch-Schönlein purpura. After reviewing the literature

extracting the data and evaluating the quality by using the Cochrane systematic review method

statistical analysis was performed by using RevMan 5.3. Continuous variables were calculated by the mean differences (MD) with 95% CI

whereas dichotomous variables were calculated by odds ratio (OR). Results: A total of 9 randomized controlled studies were enrolled

including 513 children

of which 249 were in the gamma globulin combined with glucocorticoid group and 264 in the glucocorticoid alone group. Meta-analysis showed that compared with glucocorticoid alone

gamma globulin combined with glucocorticoid could relieve clinical symptoms of rash

abdominal pain

hematozoia and joint swelling and pain

and shorten the length of stay (P<0.05). The total effective rate of gamma globulin combined with glucocorticoid in the treatment of children with abdominal Henoch-Schönlein purpura was higher than that of glucocorticoid alone (P<0.05). The six-month recurrence rate of gamma globulin combined with glucocorticoid in the treatment of children with abdominal Henoch-Schönlein purpura was lower than that of glucocorticoid alone (P<0.05). Conclusion: The efficacy of gamma globulin combined with glucocorticoid in the treatment of children with abdominal Henoch-Schönlein purpura is better than glucocorticoid alone