Objective: To investigate and analyze the off-label drug use in the pediatric outpatients

so as to provide reference for rational drug use in pediatrics. Methods: Pediatric outpatient prescriptions in our hospital from Jul. to Dec. 2019 were randomly extracted to determine whether off-label drug use was used according to drug instructions

and the types of off-label drug use

age of children and distribution of drug types were statistically analyzed. Results: A total of 1

200 outpatient prescriptions were selected

including 3

285 medical orders. The proportion of off-label drug use prescriptions was 29.42%

and the proportion of off-label drug use medical orders was 18.60%. The main types of off-label drug use were no information on drug use for children (45.17%) and off-label indication (24.39%). Off-label drug use mainly occurred in infancy (32.25%) and preschool age (21.27%)

and the drug categories were mainly respiratory system drugs (27.17%)

Chinese patent medicines (24.01%) and anti-infective drugs (22.92%). Conclusion: Off-label drug use is common in pediatric outpatients

relevant laws and regulations should be formulated and supervision of off-label drug use should be strengthened in hospitals to ensure the safety and rationality of drug use in children.