Yu Liting, Jiang Yuelian, Li Lan, et al. Pharmaceutical Practice for Treatment of Children with Pseudomonas Aeruginosa Sepsis after Bone Marrow Transplantation by Clinical Pharmacists[J]. 2022,28(5):14-17.
Yu Liting, Jiang Yuelian, Li Lan, et al. Pharmaceutical Practice for Treatment of Children with Pseudomonas Aeruginosa Sepsis after Bone Marrow Transplantation by Clinical Pharmacists[J]. 2022,28(5):14-17. DOI: 10.13407/j.cnki.jpp.1672-108X.2022.05.004.
: Objective: To provide reference for clinical pharmacists to participate into the treatment of Pseudomonas aeruginosa infection in children with severe aplastic anemia after bone marrow transplantation. Methods: Clinical pharmacists participated into the treatment of P. aeruginosa sepsis in a child with severe aplastic anemia after bone marrow transplantation
and the initial treatment including antibacterial drugs such as meropenem
norvancomycin
vancomycin and amikacin
anti-fungal drugs such as fluconazole
voriconazole and micafennet
and compound sulfamethoxazole was used to prevent Pneumocystis carinii
yet the symptoms were not significantly improved. The blood culture of the child was carbapenem-resistant P. aeruginosa. After consultation
the clinical pharmacists adjusted the anti-infection treatment regimen to ceftazidime/avibatam
ciprofloxacin and micafenstine. Results: The body temperature returned to the normal state after 5 d of adjustment of the treatment regimen
and the infection indicators were improved significantly. Conclusion: The participation of clinical pharmacists can provide more targeted treatment for sepsis in children after bone marrow transplantation.