Objective: To investigate the current status and problems of microecological preparations in the pediatric clinics of the First Hospital of Jilin University. Methods: Prescription of microecological preparations in the pediatric clinics of our hospital from Jan. to Dec. 2019 was retrieved through the hospital information system (HIS). The general information

varieties of microecological preparations and off-label drug use were statistically analyzed according to the drug instructions. Results: A total of 10

372 prescriptions of microecological preparations were extracted

including Saccharomyces boulardii preparations (2

580 pieces

24.87%)

triple live bacteria of Clostridium butyricum enterococcus triple viable bacterial tablet (2

648 pieces

25.53%)

Clostridium typhimurium powders (4

564 pieces

44.01%)

Bifidobacterium triplet enteric-coated capsules (144 pieces

1.39%) and Bifidobacterium quadruple live bacteria (436 pieces

4.2%). Off-label use of microecological preparations mainly included off-label indications (6

272 pieces

60.47%)

off-label usage and dosage (4

504 pieces

43.42%) and off-label adaptation population (450 pieces

4.34%). Conclusion: Microecological preparations have a higher percentage of off-label use in pediatric medicines

and the prescription behavior of medical personnel should be standardized. Meanwhile

relevant national departments should inspire the drug manufacturers to complete and revise the relevant information on children’s medication in the drug instructions of microecological preparations in a timely manner

so as to ensure the rationality and safety of medication for children