Objective: To probe into the distribution characteristics and drug resistance of Haemophilus influenzae in children from Huizhou

so as to provide reference for rational clinical drug use. Methods: The distribution of 475 strains of H. influenzae in Maternity and Child Healthy Care and Birth Control Service Center of Huizhou from Jan. 2017 to Mar. 2019 was analyzed retrospectively

and drug sensitivity test was performed by K-B method. Results: The infection rate of H. influenzae was 98.31% in pediatric patients. The main types of specimens were sputum

accounting for 97.89%. Different from previous reports

the epidemic time was mainly concentrated from Mar. to Jun. each year. The drug resistance rate of H. influenzae to ampicillin and cefuroxime increased year by year

from 58.15% and 33.70% in 2017 to 78.57% and 62.50% in the first quarter of 2019 (P<0.05). The drug resistance rate of H. influenzae to ceftriaxone increased year by year

from 5.43% in 2017 to 19.64% in 2019 (P<0.05). The drug resistance rate to compound sulfamethoxazole was relatively high

yet there was a downward trend. The sensitivity to meropenem and levofloxacin was relatively high. Conclusion: According to the epidemic time of H. influenzae

the pathogenic bacteria infection in children can be diagnosed more empirically

and the drug resistance analysis of H. influenzae could better guide the rational use of drugs in clinical practice.