Objective: To probe into the value of using the self-defined rules of prescription pre-review system in regulating the prescribing behavior of clinicians and promoting the rational application of oral Chinese patent medicine in pediatrics. Methods: (1) A total of 14

057 prescriptions with Chinese patent medicine in the pediatric outpatient department of our hospital from Jan. to Aug. in 2020 before intervention of prescription review rules were extracted through the hospital information system. Review analysis was performed according to relevant prescription review requirements. (2) According to the review results

the common irrational drug use phenomena were classified and set under the self-defined rules of prescription pre-review system

and the repeated use of pediatric Chinese patent medicine before and after intervention of self-defined rules of prescription pre-review system were compared and analyzed. Results: After intervention of self-defined rules

the incidence of repeated use of pediatric Chinese patent medicine was 0.69%

significantly lower than 2.53% before intervention of self-defined rules. Conclusion: The intervention of self-defined rules of prescription pre-review system can significantly reduce the repeated use of pediatric Chinese patent medicine

effectively improve the level of rational use of pediatric Chinese patent medicine

and ensure medication safety for children.