Objective: To probe into the children’s medication compliance and its influencing factors. Methods: Questionnaire survey was performed on 1

573 children’s family members admitted into our hospital from Dec. 2019 to Jul. 2020. According to the questionnaire results

the enrolled children were divided into the medication difficulty group (n=142) and non-medication difficulty group (n=1

431). The medication compliance of children was analyzed

and the risk factors of medication difficulty of children were analyzed by Logistic regression. Results: Of the 1

573 cases

235 cases (14.94%) were completely complied

1

027 cases (65.29%) were basically complied

169 cases (10.74%) were rarely complied

and 142 cases (9.03%) had difficulty with medication compliance. The results of multivariate Logistic regression analysis showed that children from 6 months to 3 years

non-only child

family members with occupation of manual laborers or free/full-time

dosage form of tablets

taste of traditional Chinese medicine

irrational administration without clinicians’ instructions for frequency of administration

irrational dosage without without clinicians’ instructions for dosage of administration

drug withdraw for adverse drug reactions

with intervention measures of psychological comfort or no intervention measures were independent risk factors for children’s medication difficulty (OR=2.659

2.691

1.784

1.939

2.425

2.201

2.635

2.218

2.010

1.576

1.669

P<0.05). Conclusion: The incidence of medication difficulty in children is relatively high

and the risk factors that affect children’s medication compliance are related to the age of children

non-only child

occupation of family members

dosage form

taste

administration with clinicians’ instructions for frequency of administration

dosage with clinicians’ instructions for dosage of administration

and drug withdraw for adverse drug reactions. Clinical attention should be paid and relevant measures should be taken to improve children’s medication compliance.