Objective: To optimize the extraction process of Xifeng Zhidong granules. Methods: Taking the content of gastrodin and extraction rate as indicators

orthogonal experiment combined with back propagation artificial neural network (BP-ANN) was used to optimize the extraction process of Xifeng Zhiting granules by water addition

extraction times and extraction duration. Results: The optimal extraction process was obtained as follows: the prescription amount of medicinal materials was soaked in water for 1 h

and reflux extraction was performed twice. The first extraction was 14.4 times the amount of water (measured by the weight of dry medicinal materials)

and the second extraction was 11 times the amount of water

and each extraction was performed for 75 min. Conclusion: The optimization method of orthogonal test combined with BP-ANN have high extraction efficiency

low energy consumption

stable and reliable process

which can provide experimental basis for industrial production of Xifeng Zhidong granules.