Objective: To analyze the distribution of pathogens and multidrug-resistant organisms in hospitalized infants aged from 1 to 3 months in our hospital. Methods: Retrospective analysis was performed on all kinds of specimens from infected infants aged from 1 to 3 months who were admitted into infant ward of our hospital from Jan. 2015 to Jun. 2019. The detection rates of pathogens and multidrug-resistant organisms were statistically analyzed. Results: A total of 23

217 specimens were collected and sent for examination

3

531 (15.2%) pathogens were detected

and the positive specimens were mainly sputum culture specimens (3

284 specimens) and blood culture specimens (178 specimens). The detection rates of pathogens were 8.3% in 2015

13.3% in 2016

15.8% in 2017 and 18.1% in 2018

increasing year by year (P<0.05). The top five pathogens ranked by the detection rate were respectively Haemophilus influenzae

Staphylococcus aureus

Escherichia coli

Klebsiella pneumoniae and Moraxella catarrhalis. The top five multidrug-resistant organisms ranked by the detection rate were respectively extended-spectrum β-lactamase

methicillin-resistant S. aureus

carbapenem-resistant Enterobacteriaceae

methicillin-resistant coagulase negative Staphylococci and methicillin-resistant Staphylococcus epidermidis

with detection rate of 3.0% in 2015

3.7% in 2016

3.2% in 2017 and 2.9% in 2018 (P>0.05). Conclusion: Infection specimens from the infant ward of our hospital are mainly sputum culture specimens

and the detection rate of pathogens is increasing year by year

mainly for Gram-negative bacteria

with multidrug resistance.