Objective: To retrospectively analyze the application of antifungal agents in children with invasive pulmonary fungal infection (IPFI) in respiratory department of a children’s hospital

and to investigate the current status

so as to provide reference and suggestions for rational clinical application of antifungal agents. Methods: The application of antifungal agents in hospitalized children with IPFI from 2016 to 2018 was investigated

and differences were found by comparison of information of pediatric medication (age

dosage

frequency

route of administration

solvent selection

concentration

loading dose) in fungal infection related guidelines and drug instructions. Results: One hundred and thirty-three children were enrolled in this study. According to the guidelines

all indications were in accordance with the guidelines. The selection of antifungal agents did not meet the recommendation of guidelines in one case. There were 10 cases of drug combination of antifungal agents

which were not recommended by guidelines. According to the drug instructions

there were 105 discrepancies

with the largest number of discrepancies in the dosage

totally 62 cases. There were 8 cases of interactions with other drugs that were contraindicated in the instructions. Thirty-one cases of adverse drug reactions were observed in the study. Conclusion: The indication and drug selection are basically in accordance with the guidelines. There are certain differences between the drug combination of antifungal agents and the guidelines. Age

usage and dosage of antifungal agents are different from drug instructions. In a small number of cases

the drug combination of antifungal agents and other drugs is contraindicated in the drug instructions

and clinical administration needs to be more cautious. Impaired liver and renal function and hypokalemia are the most common adverse drug reactions and should be monitored promptly during the drug administration.