Objective: To analyze the effects of ε-polylysine on bacterial colonization

ventilator-associated pneumonia (VAP) and expression levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in children with mechanical ventilation. Methods: Clinical data of 60 children with mechanical ventilation admitted into Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine from Aug. 2017 to Aug. 2019 were retrospectively analyzed. According tor ε-polylysine intervention

all patients were divided into the observation group and the control group

with 30 cases in each group. The observation group was given ε-polylysine intervention

while the control group was left untreated. The bacterial colonization

occurrence of VAP

time of mechanical ventilation

expression levels of TNF-α and IL-6 at different positions of pipelines in two groups were observed

recorded and compared. Results: On the 4th and 7th d after ventilator

the positive bacterial detection rate in the control group at the Y-type junction (66.67% and 77.67%)

inlet section (33.33% and 66.67%) and condensate section (46.67% and 80.00%) was higher than that in the observation group (0% and 0%)

the difference was statistically significant (P<0.05). The incidence of VAP in the observation group (10.00%) was lower than that in the control group (40.00%)

and the time of mechanical ventilation in the observation group (4.36±0.55) d was shorter than that in the control group (7.31±0.49) d (P<0.05). The expression levels of TNF-α (39.25±11.88

18.56±4.65) ng/mL and IL-6 (29.38±8.33

20.05±9.48) pg/mL in the observation group were lower than those in the control group on the 4th and 7th d after ventilator (P<0.05). Conclusion: The ε-polylysine method can inhibit bacterial colonization of pediatric mechanical ventilation

reduce the incidence of VAP

shorten the time of mechanical ventilation

and decrease the levels of inflammatory factors such as TNF-α and IL-6.