多西环素在儿童重症肺炎支原体肺炎中的应用价值

庞英; 雷勋明; 江南静; 朱书瑶; 朱道娟

doi:10.13407/j.cnki.jpp.1672-108X.2021.10.003

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多西环素在儿童重症肺炎支原体肺炎中的应用价值

论著（儿科药物治疗学） | 更新时间：2022-11-03

- 多西环素在儿童重症肺炎支原体肺炎中的应用价值
- Application Value of Doxycycline in Children with Severe Mycoplasma Pneumoniae Pneumonia
- 儿科药学杂志 2021年27卷第10期页码：9-11
- 作者机构：
  
  四川省妇女儿童医院,四川,成都,610000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672-108X.2021.10.003
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-10-10，
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庞英, 雷勋明, 江南静, 等. 多西环素在儿童重症肺炎支原体肺炎中的应用价值[J]. 儿科药学杂志, 2021,27(10):9-11.

Pang Ying, Lei Xunming, Jiang Nianjing, et al. Application Value of Doxycycline in Children with Severe Mycoplasma Pneumoniae Pneumonia[J]. 2021,27(10):9-11.
庞英, 雷勋明, 江南静, 等. 多西环素在儿童重症肺炎支原体肺炎中的应用价值[J]. 儿科药学杂志, 2021,27(10):9-11. DOI： 10.13407/j.cnki.jpp.1672-108X.2021.10.003.

Pang Ying, Lei Xunming, Jiang Nianjing, et al. Application Value of Doxycycline in Children with Severe Mycoplasma Pneumoniae Pneumonia[J]. 2021,27(10):9-11. DOI： 10.13407/j.cnki.jpp.1672-108X.2021.10.003.

摘要

目的：观察多西环素对8岁以上儿童重症肺炎支原体肺炎（SMPP）的疗效。方法：回顾性研究我院2017-2019年年龄>8岁SMPP住院患儿的病历资料，随机抽取使用多西环素病例46例为多西环素组和使用阿奇霉素病例52例为阿奇霉素组。多西环素组患儿给予多西环素口服（2.2 mg/kg，bid），阿奇霉素组患儿给予阿奇霉素静脉滴注（10 mg/kg，qd），疗程5~7 d，比较两组患儿的退热时间、咳嗽缓解时间、肺部啰音消失时间、住院时间、激素使用率及血常规、C反应蛋白（CRP）、乳酸脱氢酶（LDH）、肺内病变吸收等情况。结果：两组患儿均治愈或好转，多西环素组退热时间、咳嗽缓解时间、肺部啰音消失时间、住院时间、糖皮质激素使用率及LDH、CRP水平均短于或低于阿奇霉素组，肺内病变吸收率高于阿奇霉素组（P均<0.05）。结论：8岁以上儿童SMPP口服多西环素治疗安全、有效、价廉。

Abstract

Objective: To observe the efficacy of doxycycline in severe Mycoplasma pneumoniae pneumonia (SMPP) in children over 8 years old. Methods: Medical records of children over 8 years old with SMPP in our hospital from 2017 to 2019 were retrospectively analyzed. Forty-six patients with doxycycline were randomly extracted as the doxycycline group and 52 cases with azithromycin were randomly selected as the azithromycin group. Doxycycline group was given doxycycline orally (2.2 mg/kg

bid)

and azithromycin group was given azithromycin by intravenous infusion (10 mg/kg

qd)

both groups were treated for 5 to 7 d. The duration of fever

relief time of cough

disappearance time of pulmonary rales

length of stay

application rate of hormone

blood routine

C-reactive protein (CRP)

lactate dehydrogenase (LDH)

absorption of pulmonary lesions in two groups were compared. Results: Children in both groups were cured or improved. The duration of fever

relief time of cough

disappearance time of pulmonary rales

length of stay

application rate of hormone

LDH and CRP in the doxycycline group were shorter or lower than those in the azithromycin group

the absorption rate was higher than that of the azithromycin group (P<0.05). Conclusion: Oral doxycycline treatment for SMPP in children over 8 years old is safe

effective and inexpensive.

关键词

多西环素阿奇霉素肺炎支原体肺炎儿童

Keywords

oxycyclineazithromycinMycoplasma pneumoniae pneumoniachildren

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