Objective: To analyze the main pathogens and drug sensitivity changes of neonatal fungal septicemia in southwest China from 2011 to 2020

so as to provide reference for clinical optimal treatment. Methods: Clinical data of 86 cases of septicemia with fungal infection admitted into the neonatology of Children’s Hospital of Chongqing Medical University from Jan. 2011 to Aug. 2020 were retrospectively analyzed. The general data

pathogenic characteristics

drug sensitivity results

treatment and outcome were statistically analyzed. Results: Totally 86 strains of fungi were detected in the blood cultures of 86 children

including 47 strains of Candida albicans

25 strains of Candida paraplata

9 strains of Saccharomyces glabrata

3 strains of Candida portuguese

1 strain of Candida famata and 1 strain of Candida guilliermind. There was no statistically significant difference in pathogenic bacteria composition from 2011 to 2016 and from 2017 to 2020 (P>0.05). The domestic and international guidelines recommended fluconazole and amphotericin B for the treatment of neonatal fungal sepsis. Through the comparative analysis from 2011 to 2016 and from 2017 to 2020

the drug sensitivity of the main pathogenic bacteria (C. albicans

C. paraplata and S. glabrata) to fluconazole decreased (95.8% vs 78.8%

P<0.05)

and there was no significant difference in sensitivity to amphotericin B (91.7% vs 97.0%

P>0.05). Conclusion: The pathogens of neonatal fungal sepsis in the southwest are mainly Candida

which still maintains the high sensitivity to amphotericin B

while the sensitivity to fluconazole has a tendency to decrease. In children with clinically diagnosed fungal infections and negative cultures

treatment with amphotericin B may be the preferred strategy