Objective: To probe into the appropriate bilirubin level of gamma globulin in neonates with ABO hemolytic jaundice. Methods: Retrospective analysis was adopted

160 cases of neonatal ABO hemolytic jaundice admitted to neonatology department from Jun. 2016 to Feb. 2018 were extracted to be divided into the experimental group and the control group according to the application of gamma globulin

with 80 cases in each group. According to the low-risk area

low-medium-risk area

high-medium-risk area and high-risk area of the neonatal hour-specific bilirubin nomogram (Bhutani curve)

the length of stay

the duration of phototherapy and the decrease of bilirubin per hour after treatment were compared respectively

and the appropriate bilirubin level for gamma globulin was analyzed. Results: In the high-risk area and high school high-risk area

the length of stay and the total duration of phototherapy in the experimental group were shorter than those in the control group

and the decrease of bilirubin per hour after treatment was greater than that of the control group (P<0.05). In the low-medium-risk area and low-risk area

there was no statistical significant difference in the length of stay

the total duration of phototherapy and the decrease of bilirubin per hour after treatment between two groups (P>0.05). Conclusion: When bilirubin level is in the high-medium-risk area on Bhutani curve

gamma globulin therapy is more appropriate.