Objective: To probe into the clinical characteristics and influencing factors of Acinetobacter baumannii (AB) infection in intensive care unit (ICU) of a children’s hospital

so as to provide reference for the development of infection prevention and control measures. Methods: Through the software of hospital infection management and monitoring

the clinical data of 115 cases of AB infection detected in ICU of a children’s hospital from Jul. 2018 to Jun. 2019 were collected

and the status of AB separation

age and location distribution

drug resistance and influencing factors that may lead to multiple drug-resistant bacteria were investigated retrospectively. Results: Among the 115 cases of AB detected in the ICU of the hospital

70 cases (60.87%) of multiple drug-resistant AB (MDRAB) were found. AB and MDRAB were most detected in children aged from 0 to 4 years

accounting for 80.00%. The main site of detection was respiratory tract

with a total of 101 cases. AB had the highest sensitivity to compound simvastatin

the highest resistance rate to penicillins

the first and second generation cephalosporins

part of third generation and fourth generation cephalosporins. The resistance rate to carbapenems was more than 70%

and the resistance rate to β-lactamase inhibitors such as gatazabatam and sulbactam was about 70%. Multivariate Logistic regression analysis showed that mechanical ventilation with tracheal intubation ≥1 week

indwelling central venous catheter

use of carbapenem antibiotics

use of antibiotics ≥10 d were independent risk factors for multiple drug resistance of AB (P<0.05). Conclusion: In the ICU of a children’s hospital

the drug resistance rate of AB and the proportion of MDRAB is relatively high. It is necessary to improve the hand hygiene

disinfection and isolation measures in the clinical diagnosis and treatment process of ICU

strengthen the management of invasive operation such as mechanical ventilation of tracheal intubation

indwelling central venous catheter and rational use of antibiotics.