Objective: To analyze the pathogen distribution of early-onset sepsis (EOS) and late-onset sepsis (LOS) in very low/extremely low birth weight infants in our hospital

and explore its risk factors. Methods: The clinical data of very low/extremely low birth weight infants admitted to our hospital from 2012 to 2017 were collected

and all patients were divided into the EOS group

the LOS group and the control group (without sepsis). The incidence

pathogen spectrum and risk factors of sepsis were analyzed retrospectively. Results: A total of 777 very low/extremely low birth weight infants were included

including 106 cases (13.6%) in the EOS group and 245 cases (31.5%) in the LOS group. A total of 9 strains of EOS pathogenic bacteria were cultivated

of which Escherichia coli accounted for 44.4%; Klebsiella pneumoniae accounted for 39.2% of the 130 strains of LOS pathogenic bacteria. The rates of premature rupture of membranes

postpartum cardiopulmonary resuscitation and mechanical ventilation on the first day after birth in the EOS group were higher than those in the control group (P<0.05). The probability of mechanical ventilation in the LOS group was higher than that of the control group

and the probability of cesarean section was lower than that of the control group (P<0.05). Conclusion: Premature rupture of membranes

postpartum cardiopulmonary resuscitation and mechanical ventilation on the first day after birth can increase the risk of EOS

and mechanical ventilation can increase the risk of LOS.