Objective: To observe the effects of vitamin A on levels of fibroblast growth factor-19 (FGF19)

interleukin-17 (IL-17)

C peptide and lipoprotein-a (LPa) in children with type 1 diabetes

and to probe into the effects of vitamin A on the function of residual pancreatic islet β-cells and glucose and lipid metabolism in children. Methods: A total of 110 children with type 1 diabetes admitted into our hospital from Jan. 30th

2018 to Jun. 30th

2019 were extracted to be divided into the non-intervention group (n=55) and the intervention group (n=55) via the random number table. Both groups received conventional insulin therapy

and the intervention group was given vitamin A. Serum levels of vitamin A

C-peptide

LPa

FGF19 and IL-17

blood glucose

glycosylated hemoglobin (HbA1C)

C-peptide

LPa

FGF19

IL-17 and serum vitamin A before and after treatment in two groups were observed. A total of 55 children with healthy physical examination results in our hospital were selected as the control group. Results: The levels of vitamin A and C-peptide in the control group were higher than those in the intervention group and the non-intervention group before treatment

while the levels of IL-17

LPa and FGF19 were lower than those in the intervention group and the non-intervention group before treatment

with statistically significant differences (P<0.05). After treatment

the daily insulin consumption of the non-intervention group was higher than that of the intervention group

and the difference was statistically significant (P<0.05). After treatment

the levels of vitamin A and C-peptide in the intervention group were higher than those in the non-intervention group

and the levels of IL-17

LPa

and FGF19 were lower than those in the non-intervention group

with statistically significant differences (P<0.05). Conclusion: Vitamin A deficiency

impaired islet β-cells function

abnormal glucose and lipid metabolism were found in children with type 1 diabetes. Vitamin A supplementation can protect the residual islet β-cell function and improve glucose and lipid metabolism