Objective: To systematically evaluate the clinical efficacy of esmolol in the treatment of severe hand-foot-mouth disease in children. Methods: CNKI

Wanfang database

VIP database

CBM

PubMed

EMBase

the Cochrance Library were retrieved to collect the randomized controlled trials of esmolol in the treatment of severe hand-foot-mouth disease in children (the control group was treated with conventional therapy

and the experimental group received aselol on the basis of conventional therapy). According to inclusion and exclusion criteria

qualified literature was screened for evaluation

data was extracted and Meta-analysis was performed with RevMan 5.3. Results: A total of 6 related studies were collected

including 700 children. Meta-analysis showed that the serum levels of lactate dehydrogenase (LDH)

creatine kinase (CK)

creatine kinase isoenzyme (CK-MB) and norepinephrine (NE) in the experimental group after treatment were lower than those in the control group (P<0.05). Conclusion: For the children with severe hand-foot-mouth disease

the clinical efficacy can be improved by the addition of aselol on the basis of conventional treatment