Objective: To summarize the experience of intravenous immuneglobulin (IVIG) in the treatment of children with severe burn infection. Methods: Clinical data of 24 hospitalized children with severe burn infection from 2011 to 2015 were retrospectively analyzed. According to the application of IVIG treatment

all patients were divided into 14 cases in the IVIG group and 10 cases in the control group. The routine blood test

liver and kidney function

C-reactive protein (CRP)

procalcitonin (PCT)

bacterial

fungal and blood culture of wound surface of two groups were compared and analyzed. Results: All cases were second degree burn

there was no significant difference between two groups in the age

body mass and burn area (P>0.05). Before treatment

the temperature and CRP levels in the IVIG group were significantly higher than those of the control group (P<0.05)

yet there was no statistically significant difference in WBC

neutrophil ratio

platelet count

and PCT compared with the control group (P>0.05). After treatment

the body temperature

CRP and PCT levels in the IVIG group were lower than those before treatment (P<0.05). Conclusion: Children with burns of the same area and depth may have inflammatory reactions to different degrees of burn. IVIG can effectively improve the infection symptoms of severe burn and reduce the inflammatory index.