Objective: To analyze the distribution characteristics of indications of warfarin in children

to summarize the recommendations of the guidelines

so as to provide reference for the rational use of warfarin in pediatrics. Methods: Retrospective analysis was performed on warfarin use in pediatrics in Guangzhou Women and Children’s Medical Center. The diagnosis

operation and course of disease records of children were reviewed to determine the purpose of warfarin use. Recommendations of different indications in authoritative guidelines or expert consensuses drafted by the American College of Chest Physicians

American Society of Hematology

American Heart Association or Chinese Medical Association were analyzed and viewed. Results: A total of 248 children were enrolled

including 173 males and 75 females

with an average age of 5 years. There was no recommendations of anticoagulant selection for the indications such as Meso-Rex procedure for cavernous transformation of portal vein

thromboprophylaxis after liver transplantation and thromboprophylaxis of surgical correction of total anomalous pulmonary venous connection. And the guidelines did not recommend warfarin for indications including intermittent claudication

thromboprophylaxis for stent placement of peripheral artery and peripheral arterial embolism. Conclusion: The distribution characteristics of indications of warfarin use in children is special and the level of evidences for some indications is relatively low

therefore

more related researches for children are needed.