Objective: To elucidate the effective active ingredients and potential targets of Schisandra chinensis in the treatment of inflammatory bowel disease based on network pharmacology. Methods: The potential targets of active ingredients in Schisandra chinensis were predicted by bioinformatics database. Cytoscape software was used to construct the “component-target-pathway” network model of Schisandra chinensis. Results: Eight components of Schisandra chinensis had potential interactions with 17 targets. Many biological processes

including nerve ligand interaction and TNF signaling pathway

played a therapeutic role in inflammatory bowel disease. Conclusion: It was found that Schisandra chinensis could alleviate inflammatory bowel disease through multiple signaling pathways. PTGS1(COX-1) and PTGS2(COX-2) were the active regulatory targets of Schisandra chinensis. Angeloylgomisin O had significant effects on these two targets.