Objective: To probe into the effects of dexmedetomidine on hemodynamics

myocardial and brain function indexes in children with congenital heart disease during perioperative period. Methods: A total of 98 children with atrial septal defect or ventricular septal defect admitted into Hainan General Hospital and West China Second University Hospital

Sichuan University from Aug. 2016 to Aug. 2018 were extracted to be randomly divided into the observation group and the control group

with 49 cases in each group. The control group received conventional anesthesia

tracheal intubation and mechanical ventilation. The observation group was given intravenous injection of dexmedetomidine at a dose of 0.5 μg/(kg·h) on the basis of the control group until the surgery was completed. Hemodynamic indicators (heart rate

systolic blood pressure and diastolic blood pressure) were measured before cardiopulmonary bypass (CPB) surgery (T1)

10 minutes after CPB (T2)

6 hours after CPB (T3)

and 12 hours after CPB (T4). Blood was collected at the four time points. Levels of S-100β and neuron-specific enolase (NSE)

ischemia-modified albumin (IMA) and cardiac troponin I (cTnI) were detected by ELISA. Results: Compared with the control group

the heart rate of the observation group decreased at T2 and T3 (P<0.05)

while systolic and diastolic blood pressure increased (P<0.01). The levels of IMA

cTnI

S-100β and NSE in the observation group decreased at T2

T3

and T4 (P<0.01). Compared with T1

the heart rate increased at T2 and T3 in the observation group (P<0.05). There was no significant difference between systolic blood pressure and diastolic blood pressure at each time point (P>0.05). The levels of IMA

cTnI

S-100β and NSE increased significantly at T2

T3 and T4 (P<0.05). Conclusion: Dexmedetomidine can maintain the stability of arterial blood pressure in children with congenital heart disease

reduce the heart rate

improve the myocardial damage

and decrease the levels of NSE and S-100β protein.